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Platelet-rich plasma for patellar tendinopathy: a randomized controlled trial of leukocyte-rich PRP or leukocyte-poor PRP versus saline

Brief summary, from the abstract

In athletes with chronic patellar tendinopathy, a single ultrasound-guided injection of platelet-rich plasma (either leukocyte-rich or leukocyte-poor) worked no better than a saline injection when both were paired with a supervised exercise rehabilitation program.

  • Randomized controlled trial of 57 athletes with chronic patellar tendinopathy, each given a single ultrasound-guided injection of leukocyte-rich PRP, leukocyte-poor PRP, or saline, followed by 6 weeks of supervised rehabilitation.
  • No significant difference between the three groups in change in VISA-P score, pain, or patient-reported global rating of change at any timepoint, with the primary outcome at 12 weeks and follow-up to 12 months.
  • The authors conclude that neither PRP preparation outperformed saline for improving patellar tendinopathy symptoms when combined with rehabilitation.
  • Evidence is from a single trial with a modest sample size, so results should be read with that limit in mind.
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